DESCRIPTION
Modacare 400 mg is a medication that promotes wakefulness. The active ingredient present in Modacare 400 mg is Modafinil. They are especially used in adult patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea and Shift worker sleep disorder.Â
How does Modacare 400 mg work?
Modafinil promotes wakefulness and alertness by following mechanisms:
- Dopamine Reuptake Inhibition: Modafinil binds to the dopamine transporter (DAT) and blocks dopamine reuptake which boosts alertness.Â
- Monoamine and orexin activation: modafinil stimulates the release of norepinephrine, serotonin and histamine along with wakefulness promoting orexin neurons.Â
- GABA inhibition: Modafinil inhibits GABA (gamma-aminobutyric acid), the main inhibitory neurotransmitter in the brain.Â
ADDITIONAL INFORMATION
Key Features
| About Modacare 400 mg | |
| Drug class: Central Nervous system Stimulant | |
| Sub class:Â Â Non-amphetamine wake-promoting agent |
| Product details | |
| Active Ingredient | Modafinil |
| Inactive Ingredients |
Lactose Monohydrate Microcrystalline cellulose Croscarmellose sodium Povidone Magnesium stearate Pregelatinized starch |
| Packaging type | Blister |
| Pack size | 10*10 |
| Dosage | 400 mg |
| Used for | Excessive sleep disorder |
| Onset of action | 30 to 60 minutes |
| Duration of action | 10 to 12 hours |
| Manufacturer | Careclub Ltd. |
| Shelf life | 24 months after the manufacturing date |
| Country of Origin | India |
| Storage | Store at room temperature away from sunlight and moisture |
USAGE
Modacare 400 mg is used for:
- Narcolepsy
- Shift worker sleep disorder
- Obstructive sleep apnea
Off-label uses:
- Cognitive enhancement
- Chronic fatigue
- Major depressive disorder
- Attention Deficit Hyperactivity Disorder (ADHD)
DOSAGE
The typical dose of Modafinil is 200-400 mg daily though dosage recommendations may vary depending on the condition to be treated.Â
Use as and when prescribed by the healthcare provider.Â
SIDE EFFECTS
Common side effects are:
- Headache
- Dizziness
- Nausea
- Vomiting
- Indigestion
- Trouble falling asleep
- Nervousness
- Anxiety
- Runny or stuffy nose
Severe side effects are:
- Severe skin reactions like rashes, blisters, skin peeling or sores in the mouth.
- Aggressive behaviour
- Hallucinations
- Depression
- Mania
- Thoughts of self-harm
- Shortness of breath
- Irregular or rapid heart rate
- Swelling of the face, lips, tongue
- Difficulty in breathing
- Chest pain
Interactions
Opioids: Modafinil when combined with opioids can lower their blood levels and lead to extreme pain.Â
- Hormonal contraceptives: Modafinil speeds up the metabolism of estrogen and progestin making birth control pills, implants, patches or rings less effective.Â
- Blood thinners: Modafinil can reduce the effectiveness of blood thinners like warfarin.Â
- Alcohol: Concomitant use of alcohol and modafinil tablets can increase the risk of serious side effects.Â
- Seizure medications: Modafinil can inhibit the breakdown of seizure medications like diazepam, phenytoin, propranolol that leads to toxicity or higher risk of side effects.Â
- Grapefruit: Grapefruit or grapefruit juice can increase the levels of modafinil in the body as it blocks the breakdown of modafinil.Â
Precautions & Warnings
- Use with caution if you have a history of depression, mania or psychosis.Â
- Do not drive or use heavy machineries until you know how the medications affect alertness.Â
- Modafinil is a controlled substance and can be habit-forming.Â
- It is highly advised to avoid alcohol consumption
- Use the medicine only as directed by your physician.Â
- Do not stop the medication suddenly.Â
- Do not use the medication if you are allergic to modafinil or any other ingredient of the medication.Â
CONCLUSION
Modacare 400 mg is a wakefulness-promoting medication containing modafinil that is primarily prescribed to manage excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. As directed, modafinil has the potential to improve daily functioning and quality of life. Modacare 400 mg has the potential to cause side effects and interact with a number of medications so it should only be used under the supervision of a qualified healthcare provider. Always follow the healthcare provider’s instructions and take the medication at the prescribed dosage to reduce the possibility of risks and increase the chances of benefits.Â
FAQs
What is Modacare 400 mg?
Modacare 400 mg consists of Modafinil which is a wakefulness promoting agent.Â
Is Modacare 400 mg safe for daily use?
Yes. Modacare 400 mg can be safe and effective when taken as prescribed.Â
What is the duration of action of Modacare 400 mg?
The duration of action of Modacare 400 mg is 10 to 12 hours.Â
Can Modafinil be used for ADHD?
Yes. Modafinil can be used for ADHD to improve sustained attention.Â
What are the signs of Modafinil overdose?
The signs of Modafinil overdose are seizures, hallucinations, tremors, psychosis, etc.Â
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