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Modactive 200 mg US To US

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SKU: ModactiveUS006 Category: US To US

DESCRIPTION

Dopamine reuptake inhibition: Weakly blocks dopamine transporter DAT may increase extracellular dopamine in brain, especially nucleus accumbens and prefrontal cortex. Less potent than methylphenidate.
Orexin/hypocretin system: Activates orexin neurons in hypothalamus that promotes wakefulness. Narcolepsy patients are deficient in orexin.
Histamine: Increases histamine release in tuberomammillary nucleus wake signal.
GABA/Glutamate: Decreases GABA, increases glutamate in some brain areas cortical activation.
No major sympathomimetic effect: Unlike amphetamines, minimal impact on peripheral norepinephrine. Less jitteriness, less blood pressure spike.

ADDITIONAL INFORMATION

Key Features

About (Modactive 200 mg)

Drug Class: Central Nervous System Stimulant

Subclass: Non-amphetamine wake-promoting agent

Product Details
Composition	Active ingredients: Modafinil Inactive ingredients: Croscarmellose sodium lactose monohydrate Magnesium stearate Colloidal Silicon dioxide Microcrinolose
Packaging Type	Blister
Pack Size	10*10
Dosage	200 mg
Therapeutic class	Psychostimulant
Action Class	Dopamine reuptake inhibitor
Chemical class	Benzhydrylsulfinylacetamide derivative
Retailed by	Rootslifecare
Shelf Life	24 months after the date of manufacturing
Usages	Treating symptoms of Narcolepsy, Shift-work Disorder, and Obstructive Sleep Apnea
Country of Origin	India
Storage	Store at room temperature, 15°C to 30°C, away from moisture and sunlight.

USAGE

It is used in treating Excessive day time sleepiness.
Obstructive sleep Apnea (OSA) can also be treated.
It can be used in dealing with Narcolepsy.
Shift-Work Disorder can also be treated.

DOSAGE

In the case of Obstructive sleep Apnea (OSA) and Narcolepsy 200 mg dose can be taken once a day in the morning.
In the condition of Shift work disorder, it can be taken 1 hr prior to the work start.
It can be taken with or without food. Taking with food delays Tmax by 1 hr but doesn’t reduce absorption. Avoid late-day dosing as it can lead to insomnia.
If you’ve missed the dosage then do not double the dosage.

SIDE EFFECTS

Insomnia
Diarrhea
Back pain
Runny nose
Loss of appetite
Anaphylaxis
Hallucinations
Palpitations
Hypertension
Multiorgan hypersensitivity reactions
Headache
Dizziness
Aggression, suicidal thoughts, mania

Interaction

Hormonal contraceptives may lower effectiveness due to CYP3A4 induction. Can cause breakthrough bleeding/unplanned pregnancy. Use backup non-hormonal method during use and 1 month after stopping.
Cyclosporine levels may decrease resulting in increasing risk of transplant rejection.
Warfarin may interact adversely.
CYP2C19 substrate may increase the levels of diazepam, phenytoin, propranolol, omeprazole.
CYP3A4 inducers: Carbamazepine, rifampin, St. John’s Wort may decrease the modafinil levels.
Alcohol should be avoided as it may lead to severe side effects.
MAOIs may increase the risk of hypertensive reactions.

Pharmacokinetics

Absorption Well absorbed. Tmax 2–4 hrs. Food delays but doesn’t decrease extent.
Protein binding ~60%, mainly albumin.
Metabolism Liver, CYP3A4/5 primarily. Major metabolites: modafinil acid, modafinil sulfone. Both inactive.
Half-life 12–15 hrs. Supports once-daily dosing.
Excretion Urine <10% unchanged. 80% as metabolites in urine.

Precautions

Pregnant and breast-feeding women should avoid taking any such medications.
The one with Cardiac condition, cardiac disease or hypertension should avoid such medications.
If one with Psychiatric history like Risk of mania, psychosis, or suicidal ideation monitor mood changes should avoid such medications.
Severe Liver Impairment: Reduce dose to half; avoid end-stage liver failure.
Renal Impairment: Dose adjustments are usually not required, although cases of severe renal impairment require close attention.

CONCLUSION

Modactive 200 mg is modafinil containing wakefulness promoting drug. It is used in treating excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea, or shift work disorder. It may work by Inhibiting dopamine reuptake, activating orexin neuron in hypothalamus, increasing histamine release produce wake signals. It may show some side effects like insomnia, diarrhea, back pain, runny nose, loss of appetite, anaphylaxis, hallucinations, palpitations and hypertension. This may vary from person to person and to avoid such interactions and side effects need to consult healthcare provider prior taking any such medications.

FAQS

What for Modactive 200 mg is used?

Modactive 200 mg is used in dealing with excessive sleepiness conditions like Narcolepsy, Obstructive sleep Apnea (OSA), and Shift-work Disorder.

How does Modactive 200 mg work?

Modactive 200 mg may work by Inhibiting dopamine reuptake, activating orexin neuron in hypothalamus, increasing histamine release produce wake signals.

What can be the possible side effects of Modactive 200 mg?

The possible side effects of Modactive 200 mg can be insomnia, diarrhea, back pain, runny nose, loss of appetite, anaphylaxis, hallucinations, palpitations and hypertension.

Who should avoid Modactive 200 mg?

Pregnant, breastfeeding women, allergic to modafinil, and one with prior medical conditions like heart, psychiatric history, liver disease, kidney disease should avoid taking such medications.

How fast does Modactive 200 mg works

It may reach the peak plasma concentration in just 2-4 hours.