Artvigil 250

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SKU: N/A Category: Armodafinil Tablets

DESCRIPTION

Artvigil 250 mg is a Cognitive Enhancer for wakefulness, it contains armodafinil as an active ingredient with R-isomer which is responsible for wakefulness effect. It works by increasing focus and alertness by modulating neurotransmitters like dopamine, norepinephrine, histamine and orexin.

How does Artvigil 250 mg work?

Armodafinil acts as a wake-promoting agent by being a weak inhibitor of the dopamine transporter, thereby decreasing dopamine reuptake and raising extracellular dopamine concentrations, particularly in the prefrontal cortex, nucleus accumbens, and striatum. It enhances executive function, motivation, and sustained attention.
Armodafinil inhibits the norepinephrine transporter, increasing synaptic norepinephrine in arousal-promoting centers like the locus coeruleus, resulting in enhanced vigilance and reaction time.
It also provokes hypothalamic histamine release from the tuberomammillary nucleus-a major wake-promoting neurotransmitter that inhibits sleep-inducing areas, such as the ventrolateral preoptic nucleus.
Furthermore, armodafinil also seems to potentiate orexin/hypocretin signaling, thereby stabilizing wake-sleep transitions and preventing inappropriate intrusion of REM sleep or sudden sleep attacks, particularly relevant in narcolepsy.

Evidence exists for mild modulation of the glutamate and GABA systems: It increase in excitatory glutamate activity paralleled by slight reduction in inhibitory GABA tone, contributing to net cortical activation without overexcitation.

ADDITIONAL INFORMATION

Key Features

About (Artvigil 250 mg)

Drug Class: Wakefulness-promoting agent

Subclass: Eugeroic

Product Details
Composition	Active ingredients: Armodafinil 250 mg Inactive ingredients: Croscarmellose sodium, lactose monohydrate, Magnesium stearate, Povidone.
Packaging Type	Strip
Pack Size	10*10
Dosage	250 mg
Therapeutic class	Narcolepsy and Sleep Disorder Treatment
Action Class	Central Nervous System Stimulant
Chemical class	Benzhydryl Sulfinyl acetamide derivative
Manufacturer	HAB Pharma
Shelf Life	24-36 months after the date of manufacturing
Usages	Treats excessive sleepiness associated due to Obstructive Sleep Apnea, Shift-Work Disorder and Narcolepsy
Country of Origin	India
Storage	Store at room temperature, 15°C to 30°C.

DOSAGE

Starting dose of Artvigil is 150 mg.
The recommended dose can be 250 mg, do not exceed the dose in a day.
Artvigil is higher strength, formulated for such patients who required greater wakefulness support or those who have developed tolerance to lower doses.
Dosage may vary from person to person depending upon their tolerance and requirement.

USAGE

Artvigil 250 can be used in the condition of Narcolepsy, Obstructive sleep Apnea, and Shift-work Disorder.
Night shift workers, Students those who required wakefulness and focus.

SIDE EFFECTS

Headache
Nausea
Dry Mouth
Dizziness
Insomnia
Anxiety or nervousness

Interactions

Drugs like Carbamazepine, Phenytoin, Phenobarbital, Rifampin that induce CYP3A4 increase metabolism of armodafinil reduce plasma concentrations may decrease efficacy
Armodafinil is a weak inhibitor of CYP2C19 may increase levels of drugs like Diazepam, Phenytoin, Omeprazole, and Clopidogrel are metabolized by this enzyme
Armodafinil may induce CYP2C9 slightly could decrease warfarin metabolism

Pharmacokinetics

Absorption: Rapid absorption is seen when given orally, with peak plasma concentrations in 2 to 4 hours. Bioavailability is 80%, and food does not significantly influence total exposure.
Distribution: Moderate volume of distribution, approximately 42 L; about 60% bound to plasma proteins; readily crosses the blood-brain barrier to have central effects.
Metabolism: Highly metabolized by the liver; major pathway by CYP3A4.
Elimination: Half-life: 12-15 hours, Steady-state: ~3 days.
Excretion: Metabolites: main route 60% in urine and 30% in

Precautions

During pregnancy armodafinil may reacts adversely and may affects fetus so it should be avoided during pregnancy.
Consult a healthcare provider or medical professional prior using any of medications if you are with any prior medical history.
Use with caution if you are with any psychotic history or mental illness or anxiety
Avoid alcohol or any addictive items.

CONCLUSION

Artvigil 250 mg is an effective formulation of armodafinil that tends to improve excessive sleepiness conditions like Sleep Apnea, Narcolepsy and Shift-Work Disorder as the drug Artvigil acts acts as a wake-promoting agent by being a weak inhibitor of the dopamine transporter, thereby decreasing dopamine reuptake and raising extracellular dopamine concentrations, particularly in the prefrontal cortex, nucleus accumbens, and striatum. It enhances executive function, motivation, and sustained attention. It is safe and effective drug administered if taken in controlled manner and to avoid any unwanted interactions it’s necessary to consult a healthcare professional or doctor prior.

FAQS

What for Artvigil 250 mg is used?

Artvigil 250 mg is used in the condition of Sleep-Apnea, Shift-Work Disorder and Narcolepsy.

How does Artvigil 250 mg work?

Artvigil 250 mg works by inhibiting the norepinephrine transporter, increasing synaptic norepinephrine in arousal-promoting centers like the locus coeruleus, resulting in enhanced vigilance and reaction time.

What can be the possible side effects of Artvigil 250 mg?

The Possible Side effects of Artvigil 250 mg can be headache, dizziness, anxiety.

Is it safe to take with psychotic condition or symptom?

No, its not safe to take any such medications like Artvigil 250 mg in the psychotic condition or with such symptom as it may show unwanted interaction.

How long does Artvigil takes to work?

Artvigil 250 mg takes 30-60 minutes after oral administration and it shows peak action at 2-4 hours post-dose.