DESCRIPTION
Rapofil 200 mg is a wakeful productivity support i.e., focus and wakefulness medication. It may contain modafinil as an active ingredient which may helps in dealing with excessive daytime sleepiness (EDS) i.e., narcolepsy, obstructive sleep Apnea and shift work sleep Disorder (SWSD). Rapofil 200 mg may promotes sustained wakefulness, alertness and attention without the intense jitteriness or crash associated with amphetamines in therapeutic doses.
It may work by:
- Inhibiting weakly the dopamine transporter, increasing dopamine in certain brain areas, promoting wakefulness.
- It may activate wakefulness centres i.e., hypothalamus i.e., orexin and hypocretin neurons.
- It may increase histamine, norepinephrine, serotonin and glutamate, while decreasing GABA in wake promoting regions.
ADDITIONAL INFORMATION
Key Features
| About (Rapofil 200 mg) |
| Drug Class: Eugeroic |
| Subclass: CNS Stimulant |
| Â Product Details | |
| Composition | Active ingredients:
Modafinil 200 mg Inactive ingredients: Croscarmellose sodium, Lactose monohydrate, Magnesium stearate, Povidone K30 Maize Starch |
| Packaging Type | Alu-PVC Blister |
| Pack Size | 10*10 |
| Dosage | 200 mg |
| Therapeutic class | Central Nervous System Stimulant |
| Action Class | Selective Atypical Dopamine Reuptake Inhibitor |
| Chemical class | Benzhydryl Sulfinyl acetamide derivative |
| Shelf Life | 24-36 months after the date of manufacturing |
| Usages | Treats excessive sleepiness associated due to Obstructive Sleep Apnea, Shift-Work Disorder and Narcolepsy |
| Storage | Store at room temperature, 30°C. |
USAGE
- It is used in the condition of Narcolepsy, i.e., to reduce excessive daytime sleepiness (EDS) and sudden sleep attacks.
- In dealing with Obstructive Sleep Apnea (OSA), it is like adjunct to CPAP therapy for residual daytime sleepiness.
- In the condition of Shift Work Sleep Disorder (SWSD), to improve wakefulness during night shifts.
DOSAGE
Following dosage can be taken for specific Excessive Sleepiness Condition:
- Narcolepsy and OSA: 200 mg, it can be taken once a day in the morning.
- In the case of Shift work sleep Disorder (SWSD) 200 mg can be taken approximately 1 hour before the start of the work shift.
- Some clinicians may adjust to 100 mg/day or up to 400 mg/day in divided doses based on response and tolerability.
- Should be taken at the same time each day. Can be taken with or without food, but food may delay onset by approx. 1 hour.
- Elderly, hepatic impairment, and severe renal impairment may require lower doses. In the case of Narcolepsy, it can be taken once a day.
SIDE EFFECTS
- Headache
- Nausea
- Nervousness
- Anxiety
- Insomnia
- Dizziness
- Dry mouth
- Diarrhea
- Dyspepsia
- Palpitations
- Loss of appetite
- Mood changes
- Blurred vision
- Severe skin rash
- Stevens-Johnson Syndrome
- Angioedema
- Anaphylaxis
- Psychiatric symptoms
- Chest pain
Interactions
- Hormonal Contraceptives: Modafinil induces CYP3A4 and may reduce effectiveness of steroidal contraceptives pills, injections, implants. Use alternative or additional contraception during treatment and for 1 month after stopping.
- CYP3A4/5 Substrates: Reduces levels of cyclosporine, midazolam, triazolam, some HIV protease inhibitors.
- CYP2C19 Substrates: Inhibits CYP2C19, may increase levels of phenytoin, diazepam, propranolol, omeprazole, clomipramine.
- It may also interact with warfarin.
- Other CNS Stimulants: Additive effects with amphetamines, methylphenidate may increase risk of anxiety, tachycardia, hypertension.
- Alcohol and MAO Inhibitors: Caution advised.
Pharmacokinetics
- Absorption rapidly, peak plasma concentration in just 2-4 hours.
- Well absorbed. Not significantly affected by food except delayed Tmax.
- Extensively metabolized in the liver, primarily via CYP3A4/5, and hydrolysis. Main inactive metabolite is modafinil acid. Also involves CYP2C19.
- Half-life is approx. 12-15 hours for the racemic mixture. The R-enantiomer has longer half-life is approx. 15 hours. This long half-life supports once-daily dosing but can affect night time sleep if taken late.
- Excretion: Primarily via urine as metabolites
- Steady State: Reached in 2-4 days of daily dosing.
Precautions
- Avoid taking any such medications if you are allergic to modafinil and armodafinil.
- It should also be avoided in the condition of cardiovascular history of left ventricular hypertrophy, arrhythmia, hypertension etc.
- If you are with prior Psychiatric History psychosis, mania, depression, anxiety then be caution.
- In the condition of Liver Impairment Dose reduction recommended in severe hepatic impairment.
- Pregnant and Lactating women should avoid taking any such medicines as it may can affect fetus.
- Abuse Potential Schedule IV controlled substance in US. Low potential compared to amphetamines but risk of psychological dependence exists. Should not be shared.
- Not a replacement for sleep Patients should maintain good sleep hygiene. For OSA patients, CPAP should be continued.
CONCLUSION
Rapofil 200 mg can be the best and effective in dealing with excessive daytime sleepiness issues like narcolepsy, obstructive sleep apnea and also in shift work sleep disorder (SWSD). It may work by inhibiting weakly dopamine transporter and increasing the level of dopamine this may promotes wakefulness and alertness. It may have some side effects that may can vary. Side effects like nausea, dizziness, suicidal thoughts, nervousness, anxiety, insomnia, loss of appetite and mood changes. Prior taking any such medications always consult your healthcare provider to avoid any unwanted interactions.
FAQs
What for Rapofil 200 mg is used?
Rapofil 200 mg can be used in dealing with Excessive sleepiness Disorder (ESD) like narcolepsy, Obstructive sleep Apnea and Shift work Sleep Disorder (SWSD).
How does Rapofil 200 mg work?
Rapofil 200 mg may work by inhibiting weakly dopamine transporter and increasing the level of dopamine this may promotes wakefulness and alertness.
What can be the possible side effects of Rapofil 200 mg?
The possible side effects of Rapofil 200 mg can be nausea, dizziness, suicidal thoughts, nervousness, anxiety, insomnia, loss of appetite and mood changes.
Who should avoid Rapofil 200 mg?
The with prior medical history of cardiovascular, kidney, psychotic history and pregnant and lactating women should avoid taking Rapofil 200 mg.
Can Rapofil 200 mg be used in dealing with Shift work Sleep Disorder (SWSD)?
Yes, Rapofil 200 mg be used in dealing with shift work sleep Disorder (SWSD).
1 review for Rapofil 200 mg (Modafinil)
Related products
-
Modafinil TabletBuy now
Modacare 400 mg (Modafinil)
Price range: $89.00 through $469.00 Shop Now This product has multiple variants. The options may be chosen on the product page -
Modafinil TabletBuy now
Modawake 200 mg (Modafinil)
Price range: $69.00 through $449.00 Shop Now This product has multiple variants. The options may be chosen on the product page -
Modafinil TabletBuy now
Modactive 200 mg (Modafinil)
Price range: $69.00 through $449.00 Shop Now This product has multiple variants. The options may be chosen on the product page -
Modafinil TabletBuy now
Modvigil MD 200 mg (Modafinil)
Price range: $69.00 through $395.00 Shop Now This product has multiple variants. The options may be chosen on the product page
Davy Jhonus –
I’ve used Rapofil 200 mg for my daytime sleepiness and found it helpful for staying alert through long workdays. The effect felt pretty steady rather than overly stimulating.