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DESCRIPTION
Modalit 200 mg is a wakefulness-promoting drug that contains Modafinil as an active ingredient and is used to treat excessive sleepiness associated with Narcolepsy, Obstructive sleep Apnea (OSA), and shift-work disorder (SWD). It works by stimulating the release of neurotransmitters like dopamine, norepinephrine etc.
How does Modalit 200 mg work?
Modalit 200 mg containing Modafinil which is wakefulness promoting agent acts on the brains sleep-wake cycle, increasing the levels of certain natural substances that help you stay awake.
- It works by stimulating the release of neurotransmitters like dopamine, norepinephrine, and histamine that regulates the wakefulness.
- Increase the activity in brain regions responsible for attention and arousal.
- It may decrease the activity in regions that promote sleep.
- Enhance the brains ability to regulate sleep-wake cycle.
ADDITIONAL INFORMATION
Epitome of Modalit 200 mg
- Drug class: Central Nervous system (CNS) Stimulant
- Subclass: Wakefulness-promoting agent
- Composition
- Active ingredient: Modafinil 200 mg
- Inactive ingredient: Croscarmellose sodium, lactose monohydrate, magnesium stearate, and povidone.
- Packaging Type: Strip
- Pack Size: 5*2
- Dosage: 200 mg, can be taken once a day, orally in the morning for Narcolepsy and Obstructive sleep Apnea condition.
- Therapeutic class: Sympathomimetic-like agent, wakefulness-Promoting agents
- Action Class: Central Nervous System Stimulant
- Chemical class: Benzhydryl Compounds
- Manufacturer: Sun Pharmaceutical Industries Ltd, Intas Pharmaceuticals Ltd, and other
- Shelf Life: 2-3 years after the date of manufacturing
- Usage: Treats excessive sleepiness associated with Obstructive Sleep Apnea, and Narcolepsy
- Country of Origin: India
- Storage: Store at room temperature, 20°C to 25°C.
DOSAGE
- The dose 200 mg can be taken once a day, orally in the morning for Narcolepsy and Obstructive sleep Apnea condition.
- It can be taken 1-hour prior work of Shift work Disorder.
- Doctor or healthcare provider may adjust the dose on the basis of prior medical history.
USAGE
- This medication is used in the treatment of Narcolepsy.
- Obstructive Sleep Apnea symptoms can also be treated.
- Treating symptoms of Shift-Work Disorder.
Efficacy
- Narcolepsy: Improves wakefulness and reduces excessive daytime sleepiness.
- Obstructive Sleep Apnea (OSA): Reduces excessive sleepiness and improves cognitive function.
- Shift Work Disorder (SWD): Improves alertness and performance during night shifts.
SIDE EFFECTS
- Headache
- Nausea
- Nervousness
- Anxiety
- Dizziness
- Insomnia
- Diarrhea
- Back Pain
Interactions
Modafinil is wakefulness promoting drug that may interacts with:
- Cyclosporine: Modafinil can lower cyclosporine levels, making it less effective.
- Steroidal Contraceptives: Modafinil can lower the effectiveness of steroidal contraceptives, resulting in unintended pregnancies. Alternative methods of contraception should be used.
- Warfarin: Modafinil can accelerate warfarin metabolism, it is essential to adjust the dose according to individual use.
- MAO Inhibitors: Co-administration of Modafinil and MAOIs can enhance the risks of serotonin syndrome or hypertensive crisis.
- Antidepressants: Modafinil can interact with SSRIs, SNRIs, and tricyclic antidepressants, which can increase serotonin levels.
- Antipsychotics: Modafinil can lower the effectiveness of antipsychotic drugs or may lead to various side effects.
- Corticosteroids: Modafinil can enhance corticosteroid metabolism, making them less effective so to avoid such situation consult a doctor and adjust doses accordingly.
- Alcohol: Avoid alcohol while taking Modalit 200 mg to stay away from any unwanted interactions and side effects.
Pharmacokinetics
- Absorption: It is rapidly absorbed, with peak plasma concentrations at 120-240 minutes.
- Distribution: It is widely distributed, with high protein binding capacity up-to (60%).
- Metabolism: Metabolized in the liver, primarily via amide hydrolysis and then CYP3A4-mediated metabolism.
- Elimination: Excreted through urine (80%) and feces (15%).
- Half-life is almost 12-15 hours.
Safety
- Common side effects can be Headache, nausea, nervousness, anxiety, dizziness, insomnia, diarrhea, back pain, and runny nose.
- Serious side effects may be Severe rash, allergic reactions, psychiatric symptoms, and cardiovascular events.
- Contraindications i.e., Hypersensitivity to modafinil, history of angedema, or severe hypertension.
Precautions
- Cardiac risks: Use with caution in patients with heart disease or high blood pressure.
- Psychiatric risks: Monitor for signs of anxiety, depression, or psychosis.
- Hepatic impairment: Reduce dose in patients with severe liver disease.
- Renal impairment: Use with caution in patients with kidney disease.
- Pregnancy and lactation: Use only if benefits outweigh risks.
CONCLUSION
Modalit 200 mg is an effective pharmaceutical drug that tends to treat excessive sleepiness associated conditions like Narcolepsy, Obstructive sleep Apnea, and Shift Work Disorder. While generally well-tolerated it is required to consult a medical professional or health care provider to avoid any unwanted interactions and for better results.
FAQS
What for Modalit 200 mg is used?
Modalit 200 mg is used to treat excessive sleepiness associated with Narcolepsy, Obstructive sleep Apnea (OSA), and shift-work disorder (SWD).
How does Modalit 200 mg acts?
Modalit 200 mg acts by stimulating the release of neurotransmitters like dopamine, norepinephrine etc.
Is Modalit 200 mg safe for everyone?
Yes, Modalit 200 mg is generally safe for everyone, but it is recommended to consult a healthcare provider and doctor.
What can be the possible side effects of Modalit 200 mg?
The possible side effects can be Headache, Nausea, Nervousness, Anxiety, Dizziness, Insomnia, Diarrhea, Back Pain.
How long Modalit 200 mg takes to work?
Modalit 200 mg takes 60-120 minutes after taking the dose. It is at the peak after 2-4 hours.
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