Modacare 400mg

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SKU: N/A Category: Modafinil Tablet

DESCRIPTION

Modacare 400 mg is a Central Nervous System (CNS) wakefulness modulator that may contain active ingredient as Modafinil and is used to treat excessive sleepiness associated with Narcolepsy, Obstructive sleep Apnea (OSA), and shift-work disorder (SWD). It works by enhancing the level of dopamine and other neurotransmitters as

It may Inhibits sleep-promoting centres, modafinil inhibits sleep-inducing factors such as adenosine, this may promote wakefulness.
Modafinil may tends to increases the levels of neurotransmitters like dopamine, norepinephrine, and histamine which improve alertness and concentration.
Cognitive functions may get improved as Modacare 400mg improves attention, memory, and executive functions.
Manages excessive sleepiness modafinil is used to treat conditions such as narcolepsy, shift work sleep disorder, and obstructive sleep Apnea.

ADDITIONAL INFORMATION

Key Features

About (Modacare 400 mg)

Drug Class: Central Nervous System Stimulant

Subclass: Non-amphetamine wake-promoting agent

Product Details
Composition	Active ingredients: Modafinil Inactive ingredients: Croscarmellose sodium lactose monohydrate Magnesium stearate Colloidal Silicon dioxide Microcrinolose
Packaging Type	Blister
Pack Size	10*10
Dosage	400 mg
Therapeutic class	Central Nervous System Stimulant
Action Class	CNS Stimulant (non-amphetamine type)
Chemical class	Benzhydrylsulfinylacetamide derivative
Retailed by	Careclub
Shelf Life	24 months after the date of manufacturing
Usages	Treating symptoms of Narcolepsy, Shift-work Disorder, and Obstructive Sleep Apnea
Country of Origin	India
Storage	Store at room temperature, 15°C to 30°C, away from moisture and sunlight.

USAGE

In the condition of Narcolepsy, it may reduce excessive daytime sleepiness and improves daytime functioning.
In Shift Work Sleep Disorder Modacare 400 mg may help night shift workers stay alert and maintain focus.
In the condition of Obstructive Sleep Apnea (OSA), adjunct to CPAP therapy to combat residual daytime sleepiness.
Attention Deficit Hyperactivity Disorder (ADHD): Improves focus and reduces impulsivity.
Cognitive enhancement: Used off-label to boost concentration, memory, and productivity in healthy individuals.

DOSAGE

Starting Dose can be 100 mg once a day and it may be adjusted and extended up-to 400 mg according to individual requirement and tolerance.
Maximum Recommended Dose: 400 mg/day (usually split into morning and noon doses to avoid insomnia).

SIDE EFFECTS

Headache
Nausea
Nervousness / Anxiety
Dizziness
Insomnia
Diarrhea
Back pain
Runny nose
Loss of appetite
Stevens-Johnson Syndrome Angioedema
Anaphylaxis
Hallucinations
Aggression, suicidal thoughts, mania
Palpitations
Hypertension
Multiorgan hypersensitivity reactions

Drug Interactions

Metabolism of modafinil is primarily mediated through the enzyme CYP3A4, and it has the ability to act as a moderate inducer of CYP3A4
Oral Contraceptives: Tends to decrease the effectiveness, other forms of contraception should be used.
Cyclosporine, Midazolam, Triazolam: these drugs’
Opioids (codeine, fentanyl, hydrocodone): Risk of reduced anal
Sofosbuvir: Modafinil reduces the plasma levels.
Rifampin, Phenytoin, St. John’s Wort, Efavirenz: Increase rate of metabolism
Ketoconazole, Itraconazole: Inhibition of metabolism that increase levels

Pharmacokinetics

Absorption: Rapid absorption following oral administration; maximum plasma concentration within 2 – 4
Bioavailability: Approx. 90% (not affected by food).
Distribution: Volume of distribution Approx. 0.9 L/kg, 60% bound to plasma proteins.
Metabolism: Liver enzymes CYP3A4 (major), as well as CYP1A2.
Elimination: Approximately 80% as metabolites, <10% as the unchanged drug in the
Half-Life: Average 15 hours (range 9 to 21 hours), longer in liver impairment.

Precautions

The one with Cardiac condition, cardiac disease or hypertension should avoid such medications.
If one with Psychiatric history like Risk of mania, psychosis, or suicidal ideation monitor mood changes should avoid such medications.
Severe Liver Impairment: Reduce dose to half; avoid end-stage liver failure.
Renal Impairment: Dose adjustments are usually not required, although cases of severe renal impairment require close attention.

CONCLUSION

Modafinil containing Modacare 400 mg is a highly effective and safe Alertness-enhancing medication or vigilance promoting drug that is used in treating symptoms of narcolepsy, shift work disorder, and obstructive sleep apnea. It works by enhancing dopamine inhibition and other neurotransmitters inhibition with no or minimal side effects. While generally it is well-tolerated, dosage may vary from person to person according to their requirement and tolerance and side effects may also vary, for safer side always consult a healthcare provider prior using any of above medicines.